In celebration of 50 years of discoveries on Z-DNA and Z-RNA, we invite researchers to the inaugural ABZ meeting ("A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA") to be held on May 19th, 2021. This year's meeting will be virtual.
We will feature speakers from many different fields to increase awareness of the many innovative approaches available to further advance the field. Our aim to build community and to foster multidisciplinary collaborations.
Special Issue
We also accept abstracts for a joint special issue in Molecules, 'Z-DNA and Z-RNA: from Physical Structure to Biological Function'. The deadline is October 1st, 2021.
Program and Organizing Committee
Alan Herbert
InsideOutBio, Inc., USA
Quentin Vicens
University of Colorado, USA
Karen Vasquez
University of Texas, USA
Beat Vögeli
University of Colorado, USA
Speakers
Alan Herbert
InsideOutBio, Inc., USA
Jan Rehwinkel
University of Oxford, UK
Bertram Jacobs
Arizona State University, USA
Quentin Vicens
University of Colorado, USA
Beat Vögeli
University of Colorado, USA
Siddharth Balachandran
Fox Chase Cancer Center, USA
Karen Vasquez
University of Texas, USA
Yukio Kawahara
Osaka University, Japan
Andrew Oberst
University of Washington, USA
Jonathan Maelfait
Ghent University, Belgium
Zev Bryant
Stanford University, USA
Tony Sun
Rockefeller University, USA
Thirumala-Devi Kanneganti
St. Jude Children's Research Hospital, USA
Manolis Pasparakis
University of Cologne, Germany
David Stephen Pisetsky
Duke University, USA
Seok-Cheol Hong
Korea University, Korea
Qingde Wang
University of Pittsburgh, USA
Breakout rooms
Thematical breakout rooms with moderators (below) will be available during the conference. Additionally several rooms will be open as free-communications rooms.
Z-History
Shuguang Zhang
MIT, USA
Zenetics&Disease
Guliang Wang
University of Texas, USA
Z-Structure
Catherine Musselman
University of Colorado, USA
Z-binding Proteins
Heather Koehler
Emory University, USA
Program
8:00-10:00
AM (EDT)
Session I
Alan Herbert, InsideOutBio, Inc., USA
Moderator
Alan Herbert, InsideOutBio, Inc., USA
8:00 AM (EDT) Introduction
Seok-Cheol Hong, Korea University, Korea
8:20 AM (EDT) Sequence-dependent cost for Z-form shapes both torsion-driven and protein-induced B-Z transitions
Yukio Kawahara, Osaka University, Japan
8:40 AM (EDT) Deciphering the biological significance of ADAR1–Z-RNA interactions
Manolis Pasparakis, University of Cologne, Germany
9:00 AM (EDT) Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation
Jan Rehwinkel, University of Oxford, UK
9:20 AM (EDT) Recognition of Z-RNA by ADAR1 limits interferon response
Thirumala-Devi Kanneganti, PANoptosi St. Jude Children's Research Hospital, USA
9:40 AM (EDT) ZBP1-PANoptosome: Discovery of ZBP1 as an innate immune sensor of RNA virus that drives inflammatory cell death
Bertram Jacobs, Arizona State University, USA
10:00 AM (EDT) Poxvirus induced zRNA as a pathogen associated molecular pattern
10:40 AM - 1:00
PM (EDT)
Session II
Maria Poptsova, HSE University, Russia
Moderator
Alan Herbert, InsideOutBio, Inc., USA
10:40 AM (EDT) Flipons
Jonathan Maelfait, Ghent University, Belgium
11:00 AM (EDT) Z-RNA in autoinflammatory disease
David Stephen Pisetsky, Duke University, USA
11:20 AM (EDT) The Binding of Anti-DNA Antibodies to Z-DNA and other non-B DNA Conformations
Karen Vasquez, University of Texas, USA
11:40 AM (EDT) Z-DNA-induced genetic instability in cancer
Zev Bryant, Stanford University, USA
12:00 PM (EDT) Single-molecule mechanics of alternative structure formation in supercoiled DNA
Maria Poptsova, HSE University, Russia
12:20 PM (EDT) Deep-learning approach to Z-DNA prediction
Qingde Wang, University of Pittsburgh, USA
12:40 PM (EDT) Validation of the neuroinflammatory effect of the P193A mutation in Z-binding domain of ADAR1 in mouse models
1:00-2:00
PM (EDT)
Break out Social
2:00-4:00
PM (EDT)
Session III
Beat Vögeli, University of Colorado, USA
Moderator
Andrew Oberst, University of Washington, USA
2:00 PM (EDT) Regulation and sensing of endogenous RNA by ADAR1 and ZBP1
Ed Mocarski, Emory University School of Medicine, USA
2:20 PM (EDT) Vaccinia Virus E3 Prevents Sensing of Z-RNA to Block ZBP1-dependent Necroptosis
Tony Sun, Rockefeller University, USA
2:40 PM (EDT) Decoupled expression of ADAR1 isoforms reveals unique A-to-I RNA edit sites associated with presence of the Zα domain
Siddharth Balachandran, Fox Chase Cancer Center, USA
3:00 PM (EDT) The A-Z of influenza activated necroptosis
Quentin Vicens, University of Colorado, USA
3:20 PM (EDT) RNAs in Z-form: Revealing the RNA Underworld
Beat Vögeli, University of Colorado, USA
3:40 PM (EDT) ADAR1-induced Z-conformation in non-CG RNA
4:00-4:45
PM (EDT)
Closing & Next Steps Discussion
Karen Vasquez University of Texas, USA
Moderator
There are 10 minute slots available for late breaking presentations
Contacts
E-mail: info@abz.bio
- Dr. Quentin Vicens
Department of Biochemistry and Molecular Genetics, and RNA BioScience Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
E-mail: quentin.vicens@cuanschutz.edu - Dr. Beat Vögeli
Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
E-mail: beat.vogeli@cuanschutz.edu - Dr. Karen M. Vasquez
Division of Pharmacology and Toxicology, University of Texas at Austin, Dell Pediatric Research Institute, Austin, TX, USA
E-mail: karen.vasquez@austin.utexas.edu
- Dr. Maria Poptsova
Faculty of Computer Science, Big Data and Information Retrieval School, HSE University, Moscow, Russia
E-mail: mPoptsova@hse.ru - Dr. Alan Herbert
Discovery, InsideOutBio, Inc., Charlestown, MA, USA
E-mail: alan.herbert@insideoutbio.com