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Regular version of the site

In celebration of 50 years of discoveries on Z-DNA and Z-RNA, we invite researchers to the inaugural ABZ meeting ("A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA") to be held on May 19th, 2021. This year's meeting will be virtual.

We will feature speakers from many different fields to increase awareness of the many innovative approaches available to further advance the field. Our aim to build community and to foster multidisciplinary collaborations.

 

Special Issue

We also accept abstracts for a joint special issue in Molecules and International Journal of Molecular Sciences , 'Z-DNA and Z-RNA: from Physical Structure to Biological Function'. The deadline is October 1st, 2021.

Program and Organizing Committee

Alan Herbert

InsideOutBio, Inc., USA

Quentin Vicens

University of Colorado, USA

Karen Vasquez

University of Texas, USA

Beat Vögeli

University of Colorado, USA

Maria Poptsova

Higher School of Economics, Russia

Sergey Karapetyan

Higher School of Economics, Russia

 

Speakers

Alan Herbert

InsideOutBio, Inc., USA

Jan Rehwinkel

University of Oxford, UK

Bertram Jacobs

Arizona State University, USA

Quentin Vicens

University of Colorado, USA

Beat Vögeli

University of Colorado, USA

Siddharth Balachandran

Fox Chase Cancer Center, USA

 

Karen Vasquez

University of Texas, USA

Yukio Kawahara

Osaka University, Japan

Andrew Oberst

University of Washington, USA

Jonathan Maelfait

Ghent University, Belgium

Zev Bryant

Stanford University, USA

Maria Poptsova

Higher School of Economics, Russia

 

Tony Sun

Rockefeller University, USA

Thirumala-Devi Kanneganti

St. Jude Children's Research Hospital, USA

Manolis Pasparakis

University of Cologne, Germany

David Stephen Pisetsky

Duke University, USA

 

Preliminary Program

8:00-10:00
AM (EDT)

Session I

Alan Herbert, InsideOutBio, Inc., USA

Moderator


Alan Herbert, InsideOutBio, Inc., USA

8:00 AM (EDT) Introduction 


Yukio Kawahara, Osaka University, Japan

8:20 AM (EDT) Deciphering the biological significance of ADAR1–Z-RNA interactions


Manolis Pasparakis, University of Cologne, Germany

8:40 AM (EDT) Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation


Jan Rehwinkel, University of Oxford, UK

9:00 AM (EDT) Recognition of Z-RNA by ADAR1 limits interferon response


Thirumala-Devi Kanneganti, PANoptosi St. Jude Children's Research Hospital, USA

9:20 AM (EDT) ZBP1-PANoptosome: Discovery of ZBP1 as an innate immune sensor of RNA virus that drives inflammatory cell death


Ed Mocarski, Pennsylvania, USA

9:40 AM (EDT) ZBP1, E3L


 

10:15-12:15 
AM (EDT)

Session II

Maria Poptsova,  HSE University, Russia

Moderator


Alan Herbert,  InsideOutBio, Inc., USA

10:15 AM (EDT) Flipons


Jonathan Maelfait, Ghent University, Belgium

10:35 AM (EDT) Z-RNA in autoinflammatory disease


David Stephen Pisetsky, Duke University, USA

10:55 AM (EDT) The Binding of Anti-DNA Antibodies to Z-DNA and other non-B DNA Conformations


Karen Vasquez, University of Texas, USA

11:15 AM (EDT) Z-DNA


Zev Bryant, Stanford University, USA

11:35 AM (EDT) Single-molecule mechanics of alternative structure formation in supercoiled DNA


Maria Poptsova,  HSE University, Russia

11:55 AM (EDT) Z-DNA


 

12:30-1:30
PM (EDT)

 

Break out Social

 

1:45-3:45
PM (EDT)

Session III

Beat Vögeli, University of Colorado, USA

Moderator


Andrew Oberst, University of Washington, USA

1:45 PM (EDT) Regulation and sensing of endogenous RNA by ADAR1 and ZBP1


Bertram Jacobs, Arizona State University, USA

2:05 PM (EDT) Poxvirus induced zRNA as a pathogen associated molecular pattern


Tony Sun, Rockefeller University, USA

2:25 PM (EDT) Decoupled expression of ADAR1 isoforms reveals unique A-to-I RNA edit sites associated with presence of the Zα domain


Siddharth Balachandran, Fox Chase Cancer Center, USA

2:45 PM (EDT) The A-Z of influenza activated necroptosis


Quentin Vicens, University of Colorado, USA

3:05 PM (EDT) ADAR1/Z-RNA Biophysics


Beat Vögeli, University of Colorado, USA

3:25 PM (EDT) ADAR1/Z-RNA Biophysics


 

3:45-4:30
PM (EDT)

Closing & Next Steps Discussion

Karen Vasquez University of Texas, USA

Moderator

 

There are 10 minute slots available for late breaking presentations

Contacts

E-mail: info@abz.bio

  • Dr. Quentin Vicens
    Department of Biochemistry and Molecular Genetics, and RNA BioScience Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
    E-mail: quentin.vicens@cuanschutz.edu
  • Dr. Beat Vögeli
    Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
    E-mail: beat.vogeli@cuanschutz.edu
  • Dr. Maria Poptsova
    Faculty of Computer Science, Big Data and Information Retrieval School, HSE University, Moscow, Russia
    E-mail: mPoptsova@hse.ru
  • Dr. Alan Herbert
    Discovery, InsideOutBio, Inc., Charlestown, MA, USA
    E-mail: alan.herbert@insideoutbio.com