Science festival of the HSE "LUNOHOD-1" Moscow, 27 October 2018
Maria Poptsova made a presentation "DNA punctuation-hidden layer of genome annotation" in IT crater
On October 27, the HSE LUNOHOD-1 science festival was Held in which Maria Poptsova, head of The laboratory, made a presentation on "DNA punctuation-a hidden layer of genome annotation", where she answered the question "how secondary DNA structures appear at the right time in the right place and manage almost all genomic processes".
The genome is DNA. In DNA encoded the main players living cells-proteins. And that's only 1% of the total human genome. Labeled coding sequences, i.e. the sequences from which the protein will be made, are the first layer of genome annotation. At the right moment, agents find the right sequences, and the necessary protein appears. Why in some tissues of the body there is one set of proteins, and in others-the other-is the result of the second layer of annotation — epigenetics. "EPI" in Greek is "over", meaning "above the genome", and epigenetic annotation is a colorful flags scattered around the genome, but the epigenetic code is a combinatorial combination of the check boxes. And there's a third layer of genome annotation. He's invisible. He the emerges, then disappears, and never manifests itself fully. It's DNA punctuation, or a layer of secondary DNA structures. In this talk you will learn how DNA secondary structures appear at the right time in the right place and control almost all genomic processes.