Seminars 2024
17.01.2024 [online] Comparison of methods for detecting guanine quadruplexes
Zoom
Speaker: Dmitry Konovalov, research intern
The report presented a comparison of the effectiveness of the main experimental and theoretical methods for detecting quadruplexes. Their similarities, differences, main advantages and disadvantages are described.
21.02.2024 [online] Analysis of differential expression in various samples
Zoom
Speaker: Artem Voitetsky, research intern
The report presented an analysis of differential expression in different samples. RNA and small RNA samples were compared separately. The analysis examined the dependence of differential gene expression depending on the presence or absence of the ADAR and PRKRA genes. Thus, it is planned to find out how these two genes influence what. Additionally, the effect of interferon on the samples was studied.
20.03.2024 [online] Analysis of breast cancer snRNA-seq data: from primary tumor to metastases
Zoom
Speaker: Anastasia Mikhailova, research intern
Single cell sequencing (scRNA-seq) technology is an important tool for investigating cellular heterogeneity. This method provides the ability to analyze unique gene expression profiles and other intracellular parameters, which, in turn, allows the study of intracellular processes, such as tumor heterogeneity and their interaction with surrounding tissues.
17.04.2024 [online] Experiments on Z-DNA prediction by trained machine learning models
Zoom
Speaker: Beknazarov Nazar, research intern
The study and prediction of Z-DNA regions in various organisms has become relevant. The report presents experiments on predicting Z-DNA using machine learning models trained on experimental markings and analysis of the resulting predictions, followed by comparison of the conclusions obtained on different organisms.
15.05.2024 [online] Creating a Joint Track for Z-Flipon Prediction
Zoom
Speaker: Nazar Beknazarov, research intern
To accomplish this task, approaches developed for other tasks, such as quadruplex prediction, were considered. At the saminar, approaches that can be successful in this task were discussed, the results obtained were tested on current experimental data, and the best options were selected. The results will be published.
29.05.2024 [online] Regulation of cell death pathways in cancer samples by ADAR and PRKRA
Zoom
Speaker: Artem Voitetsky, research intern
In this research project, we aimed to study the effect of ADAR and PRKRA gene knockout, as well as the effect of interferon on the transcriptome. These genes play important roles in RNA regulation and interferon response, making them promising targets for therapeutic interventions. ADAR was found to have a significant effect on RNA editing, and knockout of ADAR and PRKRA resulted in changes in the expression of their associated genes. A particularly strong link was found between the study results and lung cancer.
03.06.2024 [online] Study of signaling pathways for suppressing the immune response
Zoom
Speaker: Anastasia Mikhailova, research intern
The study performed a systematic analysis of single-cell profiles of primary breast cancer tumors and their bone marrow metastases. Key patterns of interaction between tumor cells and their microenvironment have been identified. Particular attention was paid to the MIF and MDK signaling pathways, which play an important role in the metastasis process by modulating the immune response and promoting the growth and survival of cancer cells. These results indicate the promise of these signaling pathways as targets for therapeutic intervention in metastatic breast cancer.
22.06.2024 [online] Quadruplexes in promoter-enhancer interactions
Zoom
Speaker: Dmitry Konovalov, research intern
The report presented a description of the interaction model of quadruplexes within a promoter-enhancer pair. The model assumes stacking of quadruplexes to stabilize the promoter-enhancer loop. The results of testing the model were presented, and the results of a statistical analysis of experimental data on the colocalization of quadruplexes were presented.
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