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Научный семинар НУЛ БИО: Ольга Пушкарёва "Studying the impact of genetic variability on chromatin architecture in humans"

Мероприятие завершено

Семинар научно-учебной лаборатории биоинформатики посвящён исследованию влияния генетической изменчивости на структуру хроматина у человека

Abstract. One of open problems in computational biology is the assessment of the genetic contribution to the development of complex phenotypic traits. The genome-wide association studies have shown that the majority of disease variants fall into the gene regulatory sequences. However, it is not always the case - for example, some noncoding variants can result in regulatory variations. Moreover, small population studies have shown that only a tiny part of this variation is related to genetics.

The talk will be based on the two studies that aim to characterize the chromatin variability in human lymphoblastoid cell lines (Waszak SM, et al. Cell, 2015 and Kumasaka N, et al. Nature Genetics, 2019) and my current work on application of these two models to the ATAC-seq data of human adipose stromal cells.

Рабочий язык семинара - английский
Начало в 18:30