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International Laboratory of Bioinformatics

SOON

The laboratory was established in 2018 to advance the field of bioinformatics at the Faculty of Computer Science. The International Laboratory of Bioinformatics is actively engaged in the development and application of the most modern methods of machine learning and artificial intelligence for the analysis of omics molecular biology data.

The main areas of scientific activity of the laboratory are:

1. Fundamental studies of the role of secondary DNA structures and their relation to the epigenetic code. The practical application of research is aimed at developing drugs that control the work of flipons – secondary DNA structures that regulate the work of the genome. In particular, a potential cancer drug has been proposed that regulates the work of the genome by incorporating one of the flipons – Z-DNA.

2. Development of pipeline analysis of genomic sequencing data, genetic panels. Complete analysis from variant to phenotype. Since 2019, the laboratory has been interacting with medical institutions and pharmaceutical companies in this area of ​​activity.

3. Machine learning in bioinformatics. Work in this direction has been carried out since 2018. The laboratory cooperates with major industrial partners.

4. Genetic research in the field of cardiogenetics, focused on creating a catalog of mutations of patients with cardiovascular diseases. In 2020, the Consortium "Genetics of сardiovascular diseases" was created.

5. Development of AI systems in bioinformatics. Development of AI systems for predicting the diagnosis and course of diseases. Since 2020, the first systems for predicting the side effects of anticoagulants, antidepressants and antipsychotics have been made within the framework of this area of scientific activity of the laboratory. This direction finds application in pharmaceutical companies.

The results of the research work of the laboratory are published in Russian and international journals. Various scientific and educational events on the research topics are regularly held, such as scientific seminars on machine learning methods in bioinformatics, summer and winter schools on bioinformatics, round tables, conferences and the annual interdisciplinary forum of the "Genetics of сardiovascular diseases" Consortium. The International Laboratory of Bioinformatics is actively collaborating with leading world-class laboratories.

News

The International Laboratory of Bioinformatics participated in the School for young scientists "Genetics and Epigenetics: Mechanisms, Structure, Function" which was held at the Biology Department of Lomonosov Moscow State University from October 29 to 30, 2022.
October 31, 2022
The 46th Interdisciplinary School-Conference "Information Technology and Systems" (ITaS) was held October 2-6, 2022.
October 06, 2022
There has been a quantum leap in the creation of scientific zoom collaborations around the world.
September 22, 2022
Between August 23rd and 25th, the HSE Faculty of Computer Science held its annual summer school on machine learning in bioinformatics. After two years of being held online, the school returned to an offline format for this year. Over three days, more than 120 participants attended lectures and seminars by leading experts in the field from institutions such as HSE University, Skoltech, AIRI, MSU, MIPT, Genotek, and Sber Artificial Intelligence Laboratory.
September 08, 2022
On September 2, the second event of the consortium "Genetics of Cardiovascular Diseases" — an interdisciplinary forum "Cardiogenetics and Bioinformatics: Realities of 2022" — was held at the Higher School of Economics, which continued the work of the consortium between the organizations that are part of the consortium. The forum was attended by heads and representatives of scientific centers and institutes from Moscow, St. Petersburg, Novosibirsk, Arkhangelsk, Tyumen, and Surgut.
September 02, 2022
On June 22, 2022, the round table of the consortium "Genetics of Cardiovascular Diseases" was held at the Russian Medical Academy for Continuing Professional Education (RMANPO), with the participation of representatives of 11 organizations.
June 24, 2022
On May 25, 2022, an online conference ABZ2022 was held at the Faculty of Computer Science.
June 21, 2022
The article "ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis" by Alexander Fedorov, Nazar Beknazarov, Alan Herbert, and Maria Poptsova was published in Nature on May 25, 2022.
May 25, 2022
The HSE University Centre of Artificial Intelligence pursues research in 25 areas. Research groups partake in conferences and seminars, write articles, and conduct workshops. It is too early to draw conclusions and summarise the results, so project heads explain how matters stand in their interviews.
March 14, 2022
On 17-21 February, at Voronovo Study Centre, the conference school Information Technologies and Systems. Bioinformatics took place.
February 28, 2022
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