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International Laboratory of Bioinformatics

SOON

The laboratory was established in 2018 to advance the field of bioinformatics at the Faculty of Computer Science. The International Laboratory of Bioinformatics is actively engaged in the development and application of the most modern methods of machine learning and artificial intelligence for the analysis of omics molecular biology data.

The main areas of scientific activity of the laboratory are:

1. Fundamental studies of the role of secondary DNA structures and their relation to the epigenetic code. The practical application of research is aimed at developing drugs that control the work of flipons – secondary DNA structures that regulate the work of the genome. In particular, a potential cancer drug has been proposed that regulates the work of the genome by incorporating one of the flipons – Z-DNA.

2. Development of pipeline analysis of genomic sequencing data, genetic panels. Complete analysis from variant to phenotype. Since 2019, the laboratory has been interacting with medical institutions and pharmaceutical companies in this area of ​​activity.

3. Machine learning in bioinformatics. Work in this direction has been carried out since 2018. The laboratory cooperates with major industrial partners.

4. Genetic research in the field of cardiogenetics, focused on creating a catalog of mutations of patients with cardiovascular diseases. In 2020, the Consortium "Genetics of сardiovascular diseases" was created.

5. Development of AI systems in bioinformatics. Development of AI systems for predicting the diagnosis and course of diseases. Since 2020, the first systems for predicting the side effects of anticoagulants, antidepressants and antipsychotics have been made within the framework of this area of scientific activity of the laboratory. This direction finds application in pharmaceutical companies.

The results of the research work of the laboratory are published in Russian and international journals. Various scientific and educational events on the research topics are regularly held, such as scientific seminars on machine learning methods in bioinformatics, summer and winter schools on bioinformatics, round tables, conferences and the annual interdisciplinary forum of the "Genetics of сardiovascular diseases" Consortium. The International Laboratory of Bioinformatics is actively collaborating with leading world-class laboratories.

News

On May 26-28, 2023, an off-site seminar of the academic personnel reserve "Effective organization of research activities and management of a scientific team" was held.
June 05
Life Science Alliance published an article "Open Access Z-flipon variants reveal the many roles of Z-DNA and Z-RNA in health and disease" 
May 11
On April 27, the International Laboratory of Bioinformatics took part in the Symposium on RNA Biology 2023 at the National Cancer Institute in the USA
May 04
Article published in the International Journal of Molecular Science
April 27
The International Bioinformatics Laboratory took part in the Conference "VII Congress of Biophysicists of Russia" on 17-23 April 2023 in Krasnodar based on the Kuban State Technological University
April 17
A member of the International Bioinformatics Laboratory participated in the International Conference "Multiscale DNA modelling from electrons to nucleosomes: 22 years of the Ascona B-DNA Consortium"  in Ascona, Switzerland. The conference was held on 16-21 April 2023
April 16
The article "Unsupervised domain adaptation methods for cross-species transfer of regulatory code signals" was published in the journal Frontiers in Big Data
March 30
International Laboratory of Bioinformatics took part in the conference "RNA Editing"
March 25
The long-awaited publication of the chapter on DeepZ by M. Poptsova and N. Beknazarov was published in the book "Z-DNA" by Kyeong Kim Kim, Vinod Kumar Subramani
March 24
On 16–20 February the student conference school Information Technologies and Systems. Bioinformatics took place. More than 100 students from HSE University, Kharkevich Institute for Information Transmission Problems, Skoltech, MSU, MIPT took part in it.
March 20
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