Семинар лаборатории биоинформатики "Fully bioresorbable, leadless, battery-free cardiac pacemaker"
Friday, April 09 at 17:00
Annotation:
Temporary cardiac pacemakers provide critical functions in pacing through periods of need during post-surgical recovery. The percutaneous leads and externalized hardware associated with these systems present, however, risks of infection and constraints on patient mobility. Furthermore, the pacing leads can become enveloped in fibrotic tissue at the electrode-myocardium interface, which thereby increases the potential for myocardial damage and perforation during lead removal. Here, we report a bioresorbable, leadless, and fully implantable cardiac pacemaker for post-operative control of cardiac rate and rhythm during a stable operating timeframe that subsequently undergoes complete dissolution and clearance via natural biological processes. A combined set of in vitro, ex vivo, and in vivo studies across mouse, rat, rabbit, canine, and human cardiac models demonstrates that these devices provide an effective, battery-free means for pacing hearts of various sizes with tailored geometries and timescales for operation and bioresorption. These features enable programmable cardiac pacing in a manner that overcomes all of the key disadvantages of traditional temporary pacing devices. As such, this novel cardiac pacemaker may serve as the basis for the next generation of post-operative temporary pacing technology.
Presenter: Igor Efimov, PhD, FNAI, FAIMBE, FAHA, FHRS Alisann and Terry Collins Professor, Department of Biomedical Engineering The George Washington University, Washington DC Editor-in-Chief, Cardiovascular Engineering & Technology
Professor Efimov is the Director of Cardiovascular Engineering Laboratory, an NIH-funded cardiovascular research and engineering laboratory, which focusses on the physiological mechanisms of cardiovascular disease and on development of novel therapies for heart diseases with emphasis on heart rhythm disorders. Professor Efimov served as an inaugural chairman of Biomedical Engineering Department at the George Washington University from January 2015 to December 2019. In 2008, Dr. Efimov founded Cardialen to develop low energy implantable electrotherapy for cardiac arrhythmias. Cardialen has raised over $30M in venture and federal funding and is conducting clinical trials worldwide. In 2020, Dr. Efimov co-founded NuSera Biosystems to develop new catheter technology for mapping and ablation of arrhythmias.
Dr. Efimov earned his M.Sc. and PhD from Moscow Institute of Physics and Technology in 1986 and 1992, respectively, and completed his postdoctoral training at the University of Pittsburgh (1992-1994). He served on the faculty of the Cleveland Clinic Foundation (1994-2000) and Case Western Reserve University (2000-2004) in Cleveland, OH, and Washington University in St. Louis, MO (2004-2015), prior to joining the George Washington University in 2015 as the founding chairman of its new BME Department.
Dr. Efimov is Fellow of National Academy of Inventors, the American Institute for Medical & Biological Engineering, the Heart Rhythm Society, the American Heart Association, etc. He has received numerous awards including: 2021 HRS Distinguished Scientist Award, RASA George Gamow Prize, Astor Visiting Fellowship at University of Oxford, Washington University Chancellor’s Hartwell Prize for Innovative Research, The Doris J.W. Escher Lectureship at Montefiore Medical Center of the Albert Einstein College of Medicine, Walter Lillehei Lectureship at University of Minnesota, Richard B. and Lynne V. Cheney Lectureship at the George Washington University, etc. Dr. Efimov held visiting professorships at the University of Bordeaux, France; University of Nizhny Novgorod and Moscow Institute of Physics and Technology, Russia.
Dr. Efimov is current Editor-in-Chief of Cardiovascular Engineering & Technology, journal of Biomedical Engineering Society. He served as Associate Editor of the American Journal of Physiology: Heart and Circulatory Physiology and IEEE Transactions in Biomedical Engineering. He has served on editorial boards of Journal of American College of Cardiology: Clinical Electrophysiology, Circulation Research, Heart Rhythm Journal, Journal of Cardiovascular Electrophysiology, Journal of Molecular and Cellular Cardiology, Scientific Reports, and other journals.
He served as a chartered member of NIH Electrical Signaling, Transporters and Arrhythmia (ESTA) Study Section. He served on numerous international expert panels of the World Bank, Canadian Academies, British Heart Foundation, Russian Ministry of Science and Education, the Royal Society of New Zeeland, Swiss National Science Foundation, National Sciences and Engineering Research Council of Canada, and other international organizations.